For me one of the enjoyable aspects of looking at the literature is to work through some mechanisms, so with that in mind I thought I’d pose the chemistry below as a brainteaser!
Last year Will produced a note about solvents with tips for how to exploit some of their properties to help in work-up. This was one of the most popular Newsletter items with over 2,200 hits!
Let us have your comments, hints and tips on solvents and work up and we'll feature the best of them in future newsletters....
Stefan G Koenig, Pam Stanford Publishing, 2013, 368 + xvii pages, $149.95, ISBN 978-981-4316-49-1
At last a book has been published which discusses Green Chemistry from a process chemistry/engineering/manufacturing viewpoint.
D.Reay, C Ramshaw and A.Harvey, IChemE, 2013, 591 + xiii pages, £95.00 ISBN 978-0-08-098304-2
This is definitely a book for process engineers rather than process chemists. It covers topics such as compact and micro-heat exchangers, reactors, separation processes and intensified mixing, after introductory chapters plot the history of process intensification followed by a brief overview of the topic.
Ever since having to use a simple Claisen rearrangement during my PhD studies I have been interested and intrigued by this and similar sigmatropic rearrangements, so papers containing this type of chemistry always catch my attention.
During recent years I have noted a number of publications about frustrated Lewis pairs (FLPs) and their ability to activate hydrogen to enable metal-free reduction of imines for instance.
Those of you that get involved in syntheses of impurities and metabolites will, I am sure, have come across some impurities and metabolites whose preparation has proven especially challenging.
Chemspec India will return on 10-11 April 2014 at the Bombay Exhibition Centre, Mumbai. The exhibition floor plan is already filling up with some of the best speciality companies confirming their participation.
Take a look at the full list of companies who have already confirmed they will be exhibiting at Chemspec India.
One-pot Reactions, Optimal Routes for Cost and Risk Management
Perhaps a sign of my age, but I still like to have paper copies of articles and still find myself getting paper copies of items that have a more peripheral interest, only to then find I have too much main-stream work to actually read them!
A while ago I commented on the use of formyl saccharin as a surrogate for using carbon monoxide in palladium-mediated carbonylation chemistry.
I have been intrigued by the increasing reports of arynes (at research scales at least) in the chemical literature over the past 5 years or so, noting of course that the ortho-TMS substituted triflates permit ready and controlled generation of these highly reactive species.
Lumbertus (Bert) Hulshof (1946 - 2013)
We sadly have to report that Dr Bert Hulshof from The Netherlands passed away on 14 October 2013. Bert had a very long and distinguished career in process chemistry and had dedicated his time over the last few years to producing detailed and comprehensive books on the subject of process R&D.
This followed a professional lifetime spent analysing and giving lectures on problems encountered when transferring processes from laboratory to plant. This collection of some 240 cases spread over 30 years was finally combined in Bert’s excellent book ‘Right First Time in Fine Chemical Process Scale-Up’.
This book will continue to be available from Scientific Update, with the proceeds going to Bert’s family. Click here for further information.
Here are some highlights from The 14th International Conference on The Scale Up Of Chemical Processes, La Jolla, CA, July 15-17, 2013. The presentations covered several areas related to The Scale Up Of Chemical Processes, which included flow chemistry, process chemistry / biochemistry development and scale up, process safety, drying, tech transfer and health-based risk assessment approaches to impurities.
H Mayr et al, (JACS, 2013, 135 (17), 6579) reports on the electrophilicities of benzaldehyde-derived iminium ions, producing a scale as shown below which I thought may be of use to chemists in the battle toward achieving the balance between a nucleophile and electrophile. Good luck!
A slightly older article – which I must have missed on first pass! M Kunishima et al (Org Lett, 2012, 14 (19), 5026) describe the synthesis and use of a novel acid-catalysed O-benzylating reagent.