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Newsletter Issue 40 November/December 2011.
Propylene Carbonate as a Replacement for Dichloroethane in Hydroacylation Reactions
Trevor Laird Hydroacylation, the addition of an aldehyde across a double or tripl...
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What's New in Process Chemistry?
Newsletter Issue 39 August/September 2011.
Dihydropyridones from Formamides
Dr John Knight T Hiyama et al (JACS, 2011, 133, (10), 3264) describe a dehydrogenative nickel catalysed...
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What's New in Process Chemistry?
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Newsletter Issue 38 May/June 2011.
What Goes Aro...
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What's New in Process Chemistry?
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Newsletter Issue 37 February/March 2011.
β-Alky...
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My document title
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Newsletter Issue 36 November/December 2010.
Topical Tips from o...
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New Deoxofluorination Reagent This paper from a Canadian company called OmegaChem describes the use of a family of novel reagents for deoxofluorination that offer advantages over reagents such as DAST and Deoxofluor. A Liquid Reagent for Red...
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Newsletter Issue 35 July/August 2010.
Asymmetric Phase Transfer Catalysis
Dr Trevor Laird Asymmetric PTCs can be made by alkylation of commercially available alkaloids such as quinine and cinchonidine. However, c...
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Fe Catalysis – Fact or Fiction? Iron catalysis has been a growing area of interest in recent years helped by the low cost and toxicity of most iron catalysts particularly when compared to Pd, Ru, Rh etc. However a recent paper1 from Carste...
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What's New in Process Chemistry? Scared that your confidential documents aren't always confidential? Make sure you keep your work more secure with Acrobat(R) 9. Get it now.
Newsletter Issue 34 April/May 2010.
Modifie...
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Fine Chemicals Manufacture with Microreactors A short review of the way in which microreactors are being used at SAFC Pharma in Switzerland has recently been published (A Weiler, Chem & Ind, 2009, Apr 27, pp 19-21). This is followed by an account o...
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Scared that your confidential documents aren't always confidential? Make sure you keep your work more secure with Acrobat(R) 9. Get it now. A Biocatalytic Process to an Atorvastatin Intermediate ...
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Cross Coupling of Aryl Halides and Grignard Reagents The Kumada cross coupling reaction is a highly atom economical coupling of Grignards with aryl or unsaturated halides catalysed by palladium and other metals. A recent...
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World Shortage of Acetonitrile Acetonitrile is one of the most useful solvents for chemical reactions, as well as being widely used in HPLC. However it is becoming in short supply. This is partly because it is produced ...
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Chiral Switches and Patentability In the 1990s it was the fashion to change from racemic drugs to single enantiomers with some notable marketing successes being Esomeprazole Escitalopram, Dexketoprofen a...
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Addition of HCl to Unactivated Olefins This simple reaction, which is taught in the first year of undergraduate chemistry, is actually rather limited in scope, addition only occurring at useful rates to strained olefins.Click on the link on the right to d...
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Asymmetric Organocatalysis: From Infancy to Adolescence Organocatalysis continues to be widely used in the academic world though there are few examples of large scale industrial use, apart from the original proline catalysed reactions reported by chemists...
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Short Commercial Route to GSK’s HIV Protease Inhibitor Brecanavir GSK have developed a short route to their drug Brecanavir in 73% yield over 4 steps with only 1 intermediate isolation The key intermediate bis-tetrahydrofuran was made via several r...
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Reduction of Tertiary Amides (without the use of Hydrides) The reduction of amides to amines is well-documented and there are many publications in the literature and choices of reagent for this important transformation but many involve the use of highly r...
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All You Need to Know About Asymmetric Phase Transfer Catalysis (PTC) Pt 2Phase-transfer catalysis (PTC) offers some advantages for scale-up, using cheap bases such as sodium hydroxide and the ability to re-use the catalyst, along with ease of product sepa...
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All You Need to Know About Asymmetric Phase Transfer Catalysis (PTC) Pt 1 The subject of asymmetric PTC has moved on a lot since the early days in the 1980’s when the group of Dolling and Grabowski at Merck were pioneering the method on the scale up of ...
