| Cross Coupling of Aryl Halides and Grignard Reagents |
The Kumada cross coupling reaction is a highly atom economical coupling of Grignards with aryl or unsaturated halides catalysed by palladium and other metals. A recent report from the group of Knochel (Malolkakes G et al, Ang Chem Int Ed, 2009, 48, 205-9) shows that with functionalised Grignards coupling can occur with aryl bromides and that this reaction proceeds via radical intermediates. 
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| Manganese Catalysed Reactions |
In recent newsletters we have highlighted examples of using iron catalysis to replace palladium in organic reactions. Manganese can also be used as an alternative to iron.
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| Quantification of an Amorphous Phase Using H/D exchange |
A group from the University of Nottingham working with a Nottingham company, Molecular Profiles, have developed a method for quantifying the amount of amorphous material in a substance by H/D exchange. .
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| For Better Peak Separation – Just Add Water |
The quantification of enantiomer mixtures is essential to determine the success of a synthesis, but HPLC separation of the peaks may not be sufficient to get accurate determinations. |
| 'Pure by NMR'? |
A paper at the end of 2008 by Steve Davies et al (Org Lett, 2008, 10 (23), 5433) raised the question of purity assessment by proton NMR.
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| Metal-Free Catalytic Hydrogenation |
Hyama Cross-Coupling of Aryl Mesylates |
Improved Reaction Conditions for Suzuki-Miyaura Couplings with Pyridylboronate Esters |
| New Methodology for Making MOM Protected Carbamates and Subsequent Deprotection |
| Deprotection – Removal of Amine Protecting Groups (phthalimide and dimethylaminosulphonyl) |
| ... and finally ... |
| ... you might be a chemist if... you carry your lab safety goggles around with you at all times, just in case... |
