Issue 30 June 2009

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Fine Chemicals Manufacture with Microreactors

A short review of the way in which microreactors are  being used at SAFC Pharma in Switzerland has recently been published (A Weiler, Chem & Ind, 2009, Apr 27, pp 19-21).  This is followed by an account of the successful introduction of microreactor processes and process intensification at DSM Austria for making fine chemicals (S Braune and P Poechlauer, ibid, 21-24).

Isocyanide-based Multicomponent Reactions “without” Isocyanides

This intriguing title of a paper refers to a method of making isocyanides “in-situ” and then reacting further in standard multicomponent reactions such as Ugi and Passerini.

From Oblivion into the Limelight: Iron Catalysis

A short highlight with 23 references on the use of iron catalysis, with particular application in domino reactions has appeared (A Furstner, Ang. Chem. Int. Ed., 2009, 48, 1364-7).

Possible Explosions When using Magnesium Nitride

Magnesium nitride has been recommended as a reagent for converting esters to amides as well as in the preparation of heterocyclics sich as dihydropyridines and pyrroles ...

Isomerisation of Allylic Alcohols to Aldehydes

The isomerisation of primary allylic alcohols to aldehydes has been achieved using an analogue of Crabtree’s iridium catalyst, normally used for hydrogenation, and by tuning the experimental conditions.

Recent Advances in the Chemistry and Biology of Naturally-Occurring Antiobiotics

This extensive review by K C Nicolaou and coworkers (Angew Chem Int Ed, 2009, 48, 660-719) covers both old and new antibiotic classes including Tetracyclines, Thiopeptide Antibiotics, Pseudomonic acids, Kinamycin C, Ramaplanin A2, Lysobactin, Abyssomicins and finally Inhibitors of Fatty-Acid Biosynthesis.

Other interesting articles ...
Iron Catalysed Synthesis 2-Arylbenzimidazoles and Benzothiazoles Under Solvent Free Conditions

Carbonylation with Carbon Dioxide

Cyclic Carbonate Formation in Water

... and finally ...
... you might be a engineer if... choosing to buy flowers for your girlfriend or upgrading your RAM is a moral dilemma.
 
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