| What Goes Around Comes Around! |
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Dr John Knight
At risk of showing my age, I recollect some 20-30 years’ ago now there was something of a proliferation of interest in organic electrochemistry, so a report by Huang et al caught my attention (Angew Chem, Int ed 2011, 50, 4, 924). The authors describe the formation of a C-C bond through the reaction of allyl, benzyl and alkyl nucleophiles to imines.
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| Portable Analytics |
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Dr John Knight
B Luy reports in Angew Chem, Int ed 2011, 50, 2, 354 the prospects of portable proton NMR. In this ‘highlights’ paper the author comments on the current status, remarking that at elats oe group has designed and built a 30MHz machine wherein the magnet weighs about 3kg and the is about the size of a tea mug.
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| Swimming Pools? |
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Dr Will Watson
Why did swimming pools get mentioned in two of the presentations at the recent Organic Process R&D conference in Clearwater, Florida?
Yes, there was a very nice pool at the hotel, but that was not the reason.
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| Ester and Amide Reduction with DEANB Complex |
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Dr Will Watson
Esters and amides can be reduced by N,N-diethylaniline:borane complex in the presence of SpiroCAT.
Aliphatic esters are reduced at room temperature whilst aromatic esters require higher temperatures, 50°C, and longer reaction times.
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| Conversion of Iodides to CF3 Groups |
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Dr Will Watson
Trifluoromethyl groups are becoming ever more common in fine chemicals, pharmaceuticals and agrochemicals, and new methods of introducing these groups are being developed. In this paper a copper mediated trifluoromethylation of hetero-aryl iodides is carried out using a trifluoromethylsulphonium salt.
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| New Books |
| Pharmaceutical Process Chemistry for Synthesis – Rethinking the Routes to Scale Up |
| This new book by Peter Harrington (ex Syntex and Roche) discusses the detailed syntheses and process chemistry for 8 drugs. For each drug substance, all synthetic routes (based on a full patent search and inside knowledge of the author) are delineated and the experimental issues of each are commented on. Eventually the author, based on detailed analysis of issues which will affect scale up economics, impurities etc concludes which route/process is best. It makes fascinating reading. Published by Wiley in 2011, this first volume comprises 370 pages and I understand the author is already preparing a second volume with another 8 different drugs. All those working in the generics industry need to have a copy of this book and there is much valuable information for all process chemists working on new drugs. |
| Green Solvents (3 Volumes) |
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These three volumes comprise volumes 4-6 of the Handbook of Green Chemistry edited by Paul Anastas and published by Wiley-VCH. Volume 4 is on Supercritical Solvents; volume 5 describes Reactions in Water; and volume 6 covers Ionic Liquids. Whilst the coverage is far too detailed for the average process chemist (and to be honest far too academic) there are one or two interesting chapters which are of industrial relevance. So it is worth getting a copy for the library (if It exists?) and browsing through the contents pages to pick out those areas of interest.
For those involved in green chemistry, this is an excellent series of volumes and provides the most up-to-date coverage of these interesting topics. The inclusion of more industrial authors would have given the series more practical value.
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| Why Not Exhibit at one of our Events? |
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Hear what Dr Sung Baek of ThalesNano, Jerry Lengren of Graver Technologies, Julia Huben of Julabo and Dr Taeho Ko of AkzoNobel think about the benefits and gains to be made from exhibiting at one of our Conferences.
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| 20 years and still as popular as ever... |
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Chemical Development & Scale Up in the Fine Chemical & Pharmaceutical Industries is our most popular Training Course. If you have attended this Course, we'd like to hear from you.
|
| ... and finally - you might be an engineer if...... |
| ... ... you spent more on your calculator than you did on your wedding ring. |
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Dates for your diary...
Click to view our 2011 Conference and Course Dates
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CONFERENCES
Modern Synthetic Methods and Chiral Europe
23 - 25 May 2011
Edinburgh, Scotland
Hazardous Chemistry for Streamlined Large Scale Synthesis
23 - 24 June 2011
Koln, Germany
The Scale-Up of Chemical Processes
11 - 13 July 2011
Boston, USA
COURSES
Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
9 - 11 May 2011
Boston, USA
Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
8 - 10 June 2011
Brussels, Belgium
Secrets of Batch Process Scale-Up
8 - 10 June 2011
Princeton, USA
Secrets of Batch Process Scale-Up
14 - 16 September 2011
Edinburgh, Scotland
Advanced Aromatic Heterocyclic Chemistry
27 - 29 September 2011
Basel, Switzerland
The Design, Development and Scale-Up of Safe Chemical Processes and Operations
28 - 30 September 2011
Princeton, USA
Stretch your training budget - register 2 or more delegates and SAVE up to 15%!
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