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Process Chemistry News

End of Year Meetings

Written by Dr John Knight on Monday, 22 December 2014. Posted in Latest News, Process Chemistry News

Review of 'Organic Process R&D' Conference India and '2nd Winter Process Chemistry' Conference, UK

process-chemistryIt's been a very busy end of 2014 for us at Scientific Update with a range of courses to deliver and conferences to attend. During the period September to end December Will and I delivered courses in France, Hungary, USA, Canada, Hungary (again), Scotland, France (again), Germany, India and England. We have also attended Scientific Update conferences during this time in Germany, India and UK. As a result I am a bit behind with my literature reading, but thought it would be interesting to comment on just a few of the titbits that stood out for me from the conferences mentioned above.

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Book Review: Greene’s “Protective Groups in Organic Synthesis

Written by Dr Trevor Laird on Tuesday, 16 December 2014. Posted in Process Chemistry News

Book Review: Greene’s “Protective Groups in Organic Synthesis
5th Edition, by Peter G M Wuts, Wiley, 2014, ISBN 9781118905074. 1360 pages, price 66-95

The long-awaited 5th Edition of this extremely valuable work has now been published covering the literature to mid-2013 and including a further 2800 new references.This fills in the gaps from the previous edition of 2006 and so covers a tremendous amount of new material. As before the material is organised in a reader-friendly fashion as in an encyclopedia so that the reader can easily locate a particular protecting group. But at the end of the book there are reactivity charts which list the best protecting groups for each functional group. Peter Wuts has done a fantastic job in collating all this useful information and putting it together in a readable fashion. Highly recommended and incredible value for money.

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Alkylating Agents and Limit Test by Colour

Written by Dr John Knight on Thursday, 20 November 2014. Posted in Process Chemistry News

Alkylating agents

During the Scientific Update conference 'Organic Process Research and Development' in Cologne in September, amongst the many great talks was a tip I had not previously come across. Thomas Allmendinger (Novartis) was describing efforts to scale-up the hydrogenolysis of the benzylic hydroxyl by first forming the carbonate with methyl chloroformate. A really interesting talk within which was a single slide describing how they used a simple colour test to monitor for residual methyl chloroformate. The reaction is shown below. They could calibrate the colour of test solutions with the residual chloroformate and although on this occasion they had to use visual comparison, in principle at least a photometric method of analysis is feasible.

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Process Chemistry Training & Conferences

Scientific Update, established in 1989 by Dr. Trevor Laird, organises conferences and training courses for industrial chemists and chemical engineers in chemical development and scale-up and many other specialist topics in organic chemistry. We also provide extensive consultancy services in these fields and edit the international scientific journal entitled Organic Process Research and Development (OPRD).

Our short intensive training courses enable scientists to learn about highly relevant topics, to broaden their knowledge and to keep abreast of new science, new technology and new techniques. A complete list of the scheduled training courses currently available can be viewed in the training section. Many of these are also available for in-house training.

Our specialist conferences provide the perfect forum for organic process chemists and chemical engineers to network with experts from industry and academia from all over the world.

Our aim is to provide you with the very best, up-to-date chemistry and superb locations. At every event, Scientific Update provide the highest quality organisation and friendly support from all our team.  We look forward to welcoming you to one of our events soon.

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