Process Chemistry News
Professor Erick Carreira (ETH, Zurich) presented work on iridium catalysed allylic substitution reactions with carbon nucleophiles using catalyst (1) during the '2nd Winter Process Chemistry' Conference in Manchester, in December 2014.
Dr Roland Goetz (BASF) gave a presentation, during the 'Organic Process R & D' Conference in Pune in December which highlighted the challenges faced in trying to identify commercially viable routes to agrochemicals, which are typically low cost products that still contain a significant degree of complexity. One point he made was that companies have to re-register products every 10 years and as a result about 70% of old active ingredients have been withdrawn, mainly due to their negative impact on the environment.
Today Quality by Design (QbD) is implemented primarily for economic considerations, and less because of possible regulatory flexibility that could be gained. The value added by QbD methodology has two components:
(i) very low cost of poor quality, and
(ii) systematically generated process understanding
(as Dr. Thien from Merck recently commented about the role of chemical process R&D: "...we make material ....and we make knowledge...").