Professor S. Flitsch, University of Edinburgh, Scotland

Professor Flitsch presented work on the use of enzymes in solid supported synthesis. Several aspects were covered including the choice of solid support, using enzymes to catalyse reactions between 2 substrates, one of which is supported, using enzymes to cleave compounds off solid supports, and analysis of enzyme reactions on immobilised substrates. Examples included the use of penicillin amidases to cleave linkers, thermolysin catalysed peptide synthesis and the use of fluorescence microscopy to follow enzyme reactions on immobilised substrates. This analytical technique correlated well with hplc data for the same reaction.