A Simple Protocol for Direct Reductive Amination of Ketones and Aldehydes
(including a.b-unsaturated carbonyl compounds)
The method described by Basudeb Basu et al uses potassium formate and catalytic palladium acetate in a transfer hydrogenation. Yields are typically in the range 60-80%. A variety of aromatic aldehydes and ketones were examined as substrates reacting with amines such as cyclohexylamine, morpholine, benzylamine and various anilines. (Synlett, 2003, (4), 555-557).