Large Scale Reactions At Low Temperature (Down To -100 oC)
A short article from the company Siemens Axiva, formerly part of Hoechst AG in Frankfurt (Partzsch S, Speciality Chem, 2002, Feb p21) illustrates the advantages of having a facility that can go down to -100oC. They needed to make a boronic acid via an organolithium intermediate containing fluorine. These decompose to benzynes at -80oC so it is really necessary to work at -90oC to successfully achieve the desired result.
