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Fluoride Free Cleavage of Triisopropylsilyl (TIPS) Protecting Groups

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Aryl TIPS ethers have been found to cleave using KOAc as catalyst and aqueous DMF as solvent at 20-70°C.  The higher temperatures are generally required for electron rich or highly hindered substrates.  Yields are consistently over 90%.

B. Wang, H.-X. Sun, B. Chen, and Z.-H. Sun, Green Chem., 2009, 1112-1114.