• Informative Presentations
  • Top Hotel Venues
  • exhibitions
  • Networking Receptions
  • Network with your Peers
  • Meet, Greet and Discuss
  • Exhibition & Networking Opportunities
  • Case Studies from leading Industry experts
  • Equipment and product demonstrations
  • Keeping you up to date
  • See the latest equipment
  • Informative and cutting edge presentations
  • Top venues in fabulous locations throughout the world
  • A warm & friendly welcome
  • Excellent networking receptions!
  • Meet & network with your Peers
  • Meet & discuss the latest technologies
  • Exhibitor opportunities at every conference!
  • Hear the latest case studies from Industry experts
  • Be the first to see new products
  • Keep up to date at Scientific Update's informative conferences
  • See the latest products and equipment demos from specialist suppliers...

A Liquid Reagent for Reductive Amination

Print
PDF
Pyridine-borane complex (py:BH3) is fairly well known as a good reagent for effecting reductive amination, but a new analogous reagent, 5-ethyl-2-methylpyridine-borane complex (PEMB) is available.  PEMB has the big advantage that it is a liquid at room temperature, has a higher thermal stability than py:BH3, and is relatively stable towards hydrolysis (5% per day in THF-water) and methanolysis (6% per day in methanol).  It is highly soluble in THF and toluene, but is insoluble in aliphatic hydrocarbons.

E.R. Burkhardt and B.M. Coleridge, Tet. Letts., 2008, 49, 5152-5155.