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Synthetic Challenges

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Here are some recent examples of drugs in Phase II, published in C & E News (April 12, 2010) and taken from an ACS meeting. The Pfizer drug SAM-531 looks fairly straightforward to make, but AZD2624, MK-4305, PF-04629991 and particularly BMS-650032 are possibly more challenging. The latter has potent antiviral activity in hepatitis C-infected patients.

trevor april 4