A morpholine amide is used in place of a Weinreb amide

07 October 2005

Weinreb amides are extremely useful intermediates, but can be expensive on an industrial scale, because of the cost of O-methylhydroxylamine hydrochloride, which is required to generate the amide in the first place. Workers at Hoffman-La Roche in Switzerland used a morpholine amide in place of a Weinreb amide, which significantly reduced the cost of the conversion step.

R. Peters et al, Org. Proc. Res. Dev., 2005, 9, 508-512.