Control Temperature When Doing Resolutions
26 March 2004
Most chemists would imagine that the best yield and enantiomeric purity would be obtained by carrying out resolutions at the lowest feasible temperature. The table below, however, shows that for each compound there is an optimum temperature for the resolution to get reasonable yield and optical purity. In the first example note the yield difference between 50 and 48°C.
Temperature dependence of resolution of pipecolic acid xylylides with tartaric acid and O,O' -dibenzoyltartaric acid.
From Optical Resolutions, Theory & Practice a Scientific Update Training course given by D. Kozma and K Marthi, Nov 2003