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- Developing Safe Chemical Reactions
- Modern Synthetic Methods & Chiral Europe
- Modern Synthetic Methods & Chiral USA
- New Horizons in Catalysis
- New Horizons in Catalysis
- Optimising Organic Reactions
- Organic Process Research & Development
- Organic Process Research and Development
- Organic Process Research and Development
- Organic Process Research and Development
- Organic Process Research and Development
- Polymorphism & Crystallization
- Polymorphism & Crystallization
- Process Analytical Technologies (PAT)
- Process Analytical Technologies (PAT)
- Synthetic Heterocyclic Chemistry
- The Scale-Up of Chemical Processes
- The Scale-Up of Chemical Processes
- Exhibitions|| Complete Exhibitor Information
- Sponsorship||Details & Benefits of Event Sponsorship
- Presentation Archive||View presentations from previous conferences
- Improvements in the Preparation of Key Intermediates in Manufacturing Processes of Torcetrapib and Ziprasidone API
- Scale Up or Blow Up: Some learnings from a century of Grignard Chemistry
- Converting Data into Knowledge
- Process Development towards an Enantiomerically Pure Aminolactam
- Application of In-Process Analytical Tools to Monitoring & Controlling the Batch Crystallisation
- Studies on Selective Monoamine Reuptake Inhibitors
- Asymmetric Synthesis with Transition Metal Catalysts
- Synthetic Methods for Process Studies on Selective Monoamine Reuptake Inhibitors
- In-Process Monitoring of Pharmaceutical Crystallisation Processes
- In Situ ATR UV-vis, a Window into a "Heterogeneous" Palladium Catalyzed Heck Coupling
- PAT, Chemometrics, and Risk Minimisation in API Production
- Biocatalytic Resolutions - Scope, Limitations and Scale-Up
- Impact of New Chiral Stationery Phases on Preparative Chromatography
- Chromatorgraphy - Past, Present and Future
- Conference Directory||A List of all Conferences
- MedChem Europe
- MedChem USA
- Industrial Biotransformations
- CHIRAL Europe and USA
- Developing Chemical Processes for Active Pharmaceutical Ingredients
- Modern Synthetic Methods & Chiral USA
- Process Analytical Technologies (PAT) in Organic Process R&D
- Laboratory Automation
- Modern Synthetic Methods & Chiral Europe
- New Horizons in Catalysis
- Optimising Organic Reactions
- Organic Process Research & Development
- Polymorphism & Crystallization
- Synthetic Heterocyclic Chemistry
- The Scale-Up of Chemical Processes
- Conferences||Current Schedule
- Training||Courses Information
- Courses||Current schedule
- A Chemist's Guide to Chemical Engineering
- A Chemist's Guide to Chemical Engineering
- ADME and hERG in Medicinal Chemistry
- Advanced Aromatic Heterocyclic Chemistry
- Advanced Aromatic Heterocyclic Chemistry
- Bridging the Gap Between Lab and Plant
- Bridging the Gap Between Lab and Plant
- Catalytic Cross Coupling Reactions in Aromatic and Heteroaromatic Synthesis
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Contemporary Strategies in Organic Synthesis
- Contemporary Strategies in Organic Synthesis
- Effective Information Retrieval
- Essential Biology for Medicinal Chemists
- Essential Catalysis
- Good Manufacturing Practices in Chemical Development
- Good Manufacturing Processes in Chemical Development
- Interfacing Chemistry with Patents
- Interfacing Chemistry with Patents
- Interfacing Chemistry with Patents
- Medicinal Chemistry
- Organic Synthesis
- Organic Synthesis
- Organic Synthesis
- Safety and Selectivity in the Scale-Up of Chemical Reactions
- Safety and Selectivity in the Scale-Up of Chemical Reactions
- Scaling from Milligrams to 1-2kg
- Scaling from Milligrams to 1-2kg
- Secrets of Batch Process Scale-Up
- Secrets of Batch Process Scale-Up
- Secrets of Batch Process Scale-Up
- Secrets of Batch Process Scale-Up
- Secrets of Batch Process Scale-Up
- Secrets of Batch Process Scale-Up
- Secrets of Batch Process Scale-Up
- Secrets of Batch Process Scale-Up
- Secrets of Batch Process Scale-Up
- Synthesis & Methods
- The Design, Development and Scale-Up of Safe Chemical Processes and Operations
- The Design, Development and Scale-Up of Safe Chemical Processes and Operations
- Transition Metal Catalysis in Aromatic and Heteroaromatic Synthesis
- Understanding Organic Reactions
- Understanding Polymorphism & Crystallisation Issues in the Pharmaceutical Industry
- In-House Training
- Course Tutors
- Dr. Swati Umbrajkar
- Dr Nicholas Powles
- Dr Krister Zetterberg, Royal Institute of Technology, Stockholm, Sweden
- Dr Michael Willis, University of Oxford, UK
- Dr Mike Williams, Associate, Scientific Update
- Mr Oliver Whelehan, Umetrics
- Dr Will Watson, Scientific Update
- Dr Bob Venugopal, Chilworth Technology Inc.
- Dr Keith Turner, Kappa Tau Consulting
- Mrs Pamela Toplis, Serengeti Information Services, UK
- Dr Terry Threlfall, University of Southampton, UK
- Professor Joe Sweeney, University of Reading, UK
- Dr Andrew Starkie, Chilworth Technology
- Professor Alan Spivey, Imperial College, UK
- Professor Victor Snieckus, Queen's University, Kingston, Canada
- Dr Jasbir Singh, HEL Ltd, UK
- Dr Stephen Rowe, Chilworth Technology
- Mr Carlos B Rosas, Consultant
- Dr Derek Robinson, Consultant
- Professor Jonathan Percy, University of Strathclyde
- Dr Clive Moores, Consultant
- Dr Keith Middle, Chilworth Technology
- Mr Francis X McConville, Consultant and Author
- Dr Katalin Marthi, Hungarian Academy of Sciences - Budapest
- Professor Steve Marsden, University of Leeds
- Professor Istvan Marko, Catholic University of Louvain
- Professor Marek Majewski, University of Saskatchewan, Canada
- Dr Peter Lowe, Novobio Limited
- Professor Guy Lloyd Jones, Bristol University
- Professor Benjamin List, Max-Planck-Institute für Kohlenforschung
- Professor Nicholas Leadbeater, University of Connecticut (USA)
- Dr Trevor Laird, Founder of Scientific Update
- Dr Richard Kwasny, Consultant
- Dr Dávid Kozma, Budapest University of Technology
- Dr John Knight, Scientific Update
- Professor Jeremy Kilburn, University of Southampton
- Professor Billy Kerr, University of Strathclyde
- Dr Corinne Kay, Med-Simple
- Dr Alison Hulme, University of Edinburgh
- Dr Rolf Hilfiker, Solvias AG, Switzerland
- Mr Dennis Hendershot, Chilworth Technology Inc.
- Dr Wayne Hayes, University of Reading
- Dr Joe Harrity, University of Sheffield, UK
- Dr Marc Halpern, PTC Communications
- Dr Nick Greeves, University of Liverpool
- Ms Carol Greaves, Greaves Brewster
- Dr Christopher Frost, University of Bath, UK
- Dr Vahid Ebadat, Chilworth Technology Inc.
- Professor Roger Davey, UMIST
- Professor David B Collum, Cornell University
- Dr Andrew Carnell, University of Liverpool
- Dr Neil R Cameron, University of Durham
- Professor Steve Caddick, University College London
- Ms Andrea Brewster, Greaves Brewster
- Professor Albrecht Berkessel, University of Cologne, Germany
- Mr Richard Ball, Chilworth Technology
- Professor John Atherton, Consultant
- Professor Alan Armstrong, Imperial College, UK
- Dr John Andraos, York University (Canada)
- Dr Geoff Lawton, Consultant
- Dr David Clark, Argenta
- Dr David Horwell, Consultant
- Dr Nigel Rogers, Consultant
- Mr Stephen Adams, Magister Ltd, UK
- Dr Ian Archer, Ingenza, UK
- Course Directory||A List of all training courses
- A Chemist's Guide to Chemical Engineering
- ADME and hERG in Medicinal Chemistry
- Advanced Aromatic Heterocyclic Chemistry
- All You Need to Know about Process Validation
- An Introduction to Organic Chemistry
- Aspects of Chemical Purification and Process Separation Technology
- Bridging the Gap Between Lab and Plant
- Catalytic Cross Coupling Reactions in Aromatic and Heteroaromatic Synthesis
- Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
- Contemporary Strategies in Organic Synthesis
- Effective Information Retrieval
- Essential Biology for Medicinal Chemists
- Essential Catalysis
- Good Manufacturing Practices in Chemical Development
- Heterocyclic Synthesis in Modern Chemistry
- Interfacing Chemistry with Patents
- Making & Using Fluoroorganic Molecules
- Medicinal Chemistry
- Organic Synthesis
- Organic Synthesis Begins with Lithium
- Practical Phase-Transfer Catalysis
- Safety and Selectivity in the Scale Up of Chemical Reactions
- Scaling from Milligrams to 1-2kg
- Secrets of Batch Process Scale-Up
- Separation of Enantiomers
- Synthesis & Methods
- The Design, Development and Scale-Up of Safe Chemical Processes and Operations
- Understanding Organic Reactions
- Understanding Polymorphism & Crystallisation Issues in the Pharmaceutical Industry
- Courses||Current schedule
- Webinars||& Other Related Events
- Scheduled Events
- 10th Winter Conference on Medicinal & Bioorganic Chemistry
- Carbon-Carbon Bond Forming Reactions
- Case Studies in Organic Process R&D
- Chemspec Europe 2010, Berlin
- Chemspec India 2010, Mumbai
- Essential Awareness Briefings - 4 Day Package
- Grignard Reactions in Process Development
- Hydride Reductions webinar
- Industrial Asymmetric Synthesis & Related Processes
- InformexUSA 2009
- Reduction Reactions in Organic Synthesis
- Scale-Up: What Goes Wrong?
- Scale-Up: What Goes Wrong?
- Scale-Up: What Goes Wrong?
- The Discovery/Early Development Interface - Challenges and Opportunities
- Webinars *NEW*
- Scheduled Events
- Publications||Newsletters & More
- OPRD Journal||Editor Trevor Laird
- Topical Tips||Useful tips from experts
- Debenzylation/ketal removal
- Reduction of Acetylenes to Olefins
- Selective reductions of haloaryl nitro compounds
- Debenzylation without competing reductive alkyaltion
- Mild and Simple Conversion of Primary Amines to N-Substituted Glycines
- Use of Ionic Liquids as Reagents for Demethylation - Lactonisation
- More Robust and Reliable Cyanation Reactions
- Work Up of Borane Reductions of Amides and Imides
- Direct Conversion of Carboxylic Acids to Trifluoromethyl Ketones
- One-Pot Conversion of Alcohols into Amides via Oximes
- Enzymatic Oxidation of Aromatic Amines
- Sodium Iodide as a Catalyst in C-C Bond Forming Reactions
- New Method of Making Tertiary Amines
- A Pressure-Dependent Asymmetric Catalytic Hydrogenation of an Unsaturated Acid
- Solvent Effects and Effect of Additives in the Asymmetric Reduction of a Key Statin Intermediate
- Toxicity of Ionic Liquids
- One-pot reduction of alcohols, aldehydes, ketones, and carboxylic acids to alkanes
- One-pot Preparation of aryl fluorides from anilines under non-aqueous conditions
- Selective deprotection of N-heteroaromatic carbamates under basic conditions
- Deoxygenation of Aromatic N-Oxides and Nitrones
- Ammonia Catalysed Aldol and Mannich Reactions
- Substituted Pyridines from Acetonitrile
- Lewis Acid Catalysed Selective Halogenation of Aromatics Using NXS(X=Cl, Br, I)
- Indium Chloride - A Good Catalyst for the Sonogashira Reaction
- Improved Synthesis of Isatins
- Direct a-Acyloxylation of Carbonyl Compounts
- Construction of 3,4,5 Trisubstituted Pyridines
- Direct Addition of Grignards to Acid Chlorides
- Don't be frightened of kinetics
- First reported scale-up of a ring closing metathesis (RCM) reaction
- A morpholine amide is used in place of a Weinreb amide
- Modifying a peptide coupling reaction leads to a much easier work-up
- Trifluoromethylation of aldehydes
- Piggyback your catalyst to get good ee and good conversion
- IBX: in situ generation
- Pd-C catalysed allylic oxidation using nitrobenzene as a hydrogen acceptor
- Buchwald-Hartwig Amination - Base Effect
- Tertiary amides from carboxylic acids
- An air-stable "methyl anion"
- Boc cleavage using sulphuric acid in dichloromethane
- Another ammonia equivalent
- Coupling of Peptides using Ethyl Propiolate
- Stereoselective Cyclisations to Form Tetrahydropyrans
- Directed Evolution improved Biocatalyst Performance in the Enantioselective Baeyer-Villiger Reaction
- Direct Aminoalkylation of Cycloalkanes
- Intramolecular Enantioselective Stetter Reaction to generate Quaternary Stereocentres
- Toxicity of ionic liquids
- One-pot Preparation of aryl fluorides from anilines under non-aqueous conditions
- 2-Pyridyl boronates - the story continues
- Alkyl hydrazines made simple
- Improved method for the oxidative cleavage of alkenes
- Ringing the changes on DMAP
- Chlorination of an aryl lithium: The importance of correct selection of Cl+ source
- Halide reductions in aqueous systems
- Inversion of Chirality - Just by Changing the Metal!
- Taming Fluorophenyl Organometallic Reagents
- Nitration Alternative
- The Chiral Pool - Lest We Forget: Chirality from Starch
- Asymmetric 1,4-addition: Highly Reactive α,β-Unsaturated Ester Surrogates
- Odourless thiols and sulfides
- Don't forget non-contaminating impurities
- Use a dicyclohexylamine salt to crystallise a carboxylic acid and upgrade compound purity
- Lithium technology - an alternative to alkyllithiums
- High-yielding crystallisation of a single enantiomer from a racemic mixture by seeding induced deracemisation
- Ever better Grignard procedures
- A robust sulfur-tolerant form of palladium for hydrogenations
- Crystallisation: When being inclusive makes a difference
- A new fluorinating reagent system: Alkyl fluorides from alcohols under mild reaction conditions
- Improved Reformatsky reaction robustness:Using a small-scale reaction to 'seed'a large-scale one
- In situ activation of an acetate ester - a novel alternative to malonate chemistry
- Direct conversion of a carboxylic acid to nitrile
- Ruthenium Scavenger
- One-carbon chain extension of esters to α-chloroketones -α safer route
- Michael addition of amines and thiols to dehydroalanines proceeds better in frozen water
- 2-Pyridyl Boronates - A Practical Solution to a Longstanding Problem
- Removal of a primary Boc group under basic conditions
- The Importance of water in a TEMPO-iodobenzene diacetate oxidation
- Are you using too much Palladium?
- Solving Emulsion Problems
- Safety of Hypervalent Iodine Reagents
- Control Temperature When Doing Resolutions
- Carry out extractions more efficiently at elevated temperatures
- Resolutions with Tartaric Acid Derivatives
- Alternative to Dichloromethane
- Conglomerates - More Common than you Think
- Understand the reaction kinetics and the rate equation to help optimisation
- Use of Biocatalysis to Distinguish Between Two Similar Groups
- Unexpected catalysis by trace metallic impurities
- Using (in)solubility to pull an equilibrium mixture of product diastereoisomers over to the desired
- Pyromellitate - a little used counterion to add to the process chemist's tool box
- Improving the robustness and scalability of of organolithium and Grignard reactions
- Hydrogenation in Water
- Are you sure your Suzuki or other cross coupling reaction requires a transition metal catalyst?
- Use if Aqueous Organic Solvents in Resolution Processes
- Water Miscible Solvents
- Solvents for Extraction
- Emulsion Formation during Extractions
- Drug companies use a range of salts to produce crystalline derivatives suitable for processing
- Process Chemistry Articles
- Oxindoles with Chiral Quarternary Carbon via Hetero-Claisen Chemistry
- Enantioselective Conjugate Reduction
- Chemoselective Hydrogenation
- Impurity formation during drying
- One Pot Procedure for Trisubstituted 1,2,4-Triazoles
- New Regioselective Pyrrolidinone Synthesis
- Propylphosphonic Anhydride (T3P®)
- Metal-Catalysed α-Arylation of Carbonyl and Related Molecules
- A Biocatalytic Process to an Atorvastatin Intermediate
- ChemTube3D - Interactive 3D Organic Reaction Mechanisms
- Catalysis of Organic Reactions
- A Mechanistic Puzzle
- C-H Hydroxylation using a Heterocyclic Catalyst
- Stereospecific C-H Oxidation by Hydrogen Peroxide using Iron Catalyst
- Flash Chemistry – Fast Organic Synthesis in Microsystems
- Chiral Diene Ligands for Asymmetric Catalysis
- An Automated-Flow Microreactor for 100g synthesis using the Sonogashira reaction
- Ortho Formylation
- A Liquid Reagent for Reductive Amination
- New Deoxofluorination Reagent
- Highlights from the 19th International Conference on Organic Process Research and Development, Fort Lauderdale FL, 27-30th April, 2009
- Highlights from Modern Synthetic Methods held in Chicago, May 11-13 2009
- Fe Catalysis – Fact or Fiction?
- Birch Reduction with Na, K on Silica Gel
- Aromatic Fluorination
- Two New Books
- Efficient Synthesis of Oseltamivir Phosphate, the Active Ingredient of Tamiflu
- Alkaline Earth Metals in Synthesis
- Alternatives to Acetonitrile as a Solvent for HPLC Analysis
- Fluoride Free Cleavage of Triisopropylsilyl (TIPS) Protecting Groups
- Recent Advances in the Chemistry and Biology of Naturally-Occurring Antiobiotics
- Isomerisation of Allylic Alcohols to Aldehydes
- Possible Explosions When using Magnesium Nitride
- Cyclic Carbonate Formation in Water
- Carbonylation with Carbon Dioxide
- Iron Catalysed Synthesis 2-Arylbenzimidazoles and Benzothiazoles Under Solvent Free Conditions
- From Oblivion into the Limelight: Iron Catalysis
- Isocyanide-based Multicomponent Reactions
- Fine Chemicals Manufacture with Microreactors
- Deprotection – removal of amine protecting groups (phthalimide and dimethylaminosulphonyl)
- New Methodology for making MOM protected carbamates and subsequent deprotection
- Improved reaction conditions for Suzuki-Miyaura couplings with pyridylboronate esters
- Hyama cross-coupling of aryl mesylates
- Metal-free catalytic hydrogenation
- 'Pure by NMR'?
- For Better Peak Separation – Just Add Water
- Quantification of an Amorphous Phase Using H/D exchange
- Manganese Catalysed Reactions
- Cross Coupling of Aryl Halides and Grignard Reagents
- Continuous Processes
- Bang Bang, You’re Dead
- Ketones from Aryl Halides and Aliphatic Aldehydes by Direct Acylation
- Hungary – the Centre of Expertise in Resolution?
- Conversion of Alcohols into Homologated Esters
- Iron catalysed Sonogashira reactions
- Amide coupling reagents
- A New Method for Desulphonating Amines
- Use of Triphenyl Phosphite and Bromine as a Mild Reagent for the Bischler-Napieralski Reaction
- World Shortage of Acetonitrile
- Chiral Switches and Patentability
- What temperature is required for the generation of metallated aromatic substrates?
- Rhodium Catalysed Direct Arylation of Pyridines and Quinolines
- Addition of CO2 to Styrenes
- Transformation of Triazoles into Imidazoles
- The Ideal Combination: Viagra® and Aspirin?
- Super Acid Catalysts In SCF Media For Production Of Linear Alkyl Benzenes
- Large Scale Buchwald Hartwig Aminations at Bayer
- Asymmetric Catalysis Utilising Alkaloid-Derived Quaternary Ammonium Salts
- Novel Stationary Phases for Analytical and Preparative Separation of Drug Enantiomers.
- Chemoenzymatic Synthesis of Pharmaceutically Important Diols
- Whiskey: Analyse it or Drink it??
- Using Phase Transfer Catalysis In Borohydride Reductions
- Focus on Consultancy
- Expert Witness Services
- 30 Years of Amino Acid and Peptide Chemistry
- Scalable Methods for Functionalised Chiral Alcohols
- Asymmetric Catalysis using Amino-Acid-Derived Ligands
- Oxidoreductases – Catalysed Syntheses of Chiral Building Blocks
- Degussa Fine Chemicals Prize Lecture - Amines and Amino Acids are Efficient Asymmetric Catalysts
- Synthesis of New Phosphines and their Applications in Asymmetric Hydrogenations
- Bringing Biocatalysis to First Generation Processes
- The Challenge of Chirality in Process Research
- A Practical Asymmetric Synthesis of the Cardiovascular Agent UK-350,926 via a Dynamic Resolution Process
- Evolution of New Bioprocesses for the Deracemisation of Amines and Unnatural Amino Acids
- The Synthesis of Omapatrilat: Issues and Challenges During Process Development
- Focus on Training
- Discovery and Applications of Enzymes for the Preparation of Enantiomerically Pure Non-Proteinogenic Amino Acids
- Automated Oligosaccharide Synthesis as Platform for Drug Discovery
- Encapsulated Catalysts
- Directed Evolution of Enzymes for Organic Synthesis
- Reflections on Process Research
- From Organometallic to OrgaNOmetallic: Microwave-promoted Organic Synthesis in Water
- Recent Advances in Methods of Parallel Synthesis
- Lithium Metal – A High Performance Alternative to BuLi
- Inventing Reactions for Atom Economy
- Catalytic Enantioselective Reductive Coupling Reactions
- Trends in Pharmaceutical Biocatalysis – Discovery, Development and Manufacturing
- A Surprise in Research is a Discovery; A Surprise in Development is a Disaster
- Large Scale Synthesis of β Amino Acids using the Rodionov Condensation
- Scale-Up of Suzuki Couplings
- Process Development for a Novel Muscarinic M3 Receptor Antagonist
- Asymmetric Synthesis in Medicinal Chemistry Collaborations
- Controlling and Exploiting Conformation in Semi-Rigid Molecules
- Enantioselective Oxidative Biaryl Coupling and Asymmetric Ketoester Allylation
- An Asymmetric Hydrogenation Based Process to Atorvastatin
- Production of Sugar Polyols by Fermentation
- Organocatalysis: A Ketone Catalysed Asymmetric Epoxidation of Olefins
- Recent Advances in the Process Chemistry of Novel AIDS Therapeutics
- Anchored Homogeneous Catalysts: High TON Applications
- Industrial Genetics: Efficient New Bioprocesses to Deracemise Amino Acids and Amines
- Fascinating Excursions into Chiral Chemistry: An Insider’s Perspective
- Industrially Successful Asymmetric Catalysis – Proven Concepts and Learnings
- Catalytic Generation of Chiral Magnesium Enolates from 1,3-Dicarbonyl Compounds: Application to the Synthesis of ABT-546
- Technical Development of Bio-Inspired Catalysts
- Microbial / Enzymatic Synthesis of Chiral Compounds
- Functional Diversity in a SCHEMA-Designed Combinatorial Library of Cytochromes P450
- Biocatalysis as a Tool for the Development of Green Processes
- Enzyme catalysis on solid phase
- New Developments in the Biocatalytic Production of Pharma Intermediates
- Developing the Biocatalyst of the Future – Screening-based Directed Evolution
- Biocatalytic Processes in Nonaqueous Environments: Benefits, Limitations and Prospects
- Enzyme Coated Microcrystals
- High-throughput Biocatalysis for Accelerated Drug Discovery and Development
- Enantiopure Alcohols by Combining Enzymatic Resolution with in-situ Racemisation
- New Biocatalytic Synthesis of Single Enantiomer Amino Acids: Protein and Reaction Engineering for Production of L-Glufosinate
- Different Strategies – One Target: Enantioselective Biocatalysis Using Lipases and Esterases
- Developing novel biocatalysts for manufacturing optically active compounds
- Direct Fermentation of Deacetylcephalosporin C
- Construction of Quaternary Stereocenters: New Perspectives through Enantioselective Michael Reactions
- Crafting Chiral Space for Asymmetric Induction in a Catalytic Synthetic Reaction
- Recent Advances in Asymmetric Transfer Hydrogenation
- Evolutionary and Combinatorial Methods in Asymmetric Catalysis
- Design, Performance, Manufacture and Industrial Use of Chiral Ligands
- Benefits and Limitations of chiral resolution via preferred crystallisation
- Cyclopropanation via a Simple Barbier Reaction in DMF
- A Simple Protocol for Direct Reductive Amination of Ketones and Aldehydes
- Pyrrolidine-2-carboxylic acid (L-Proline) as an enantioselective catalyst
- Superacid Catalysed Hydroxyalkylation of Aromatics with Ethyl Trifluoropyruvate
- Polymethylhydrosiloxane (PMHS) as an Additive in the Sonogashira Reaction
- One-pot synthesis of dihydropyrimidinones catalysed by lithium bromide
- Direct Synthesis of Propylene Oxide with CO2 as Solvent
- Direct Sulphonation of Methane to Methanesulphonic Acid with SO2 Using Ca Salts as Promoters
- Palladium-Catalysed Asymmetric Addition of Pronucleophiles to Allenes
- Novel Small Organic Molecules for a Highly Enantioselective Direct Aldol Reaction
- Selective C-Arylation of Free (NH)-Hetroarenes via Catalytic C-H bond Functionalisation
- The Pauson-Khand Reaction: the Catalytic Age Is Here
- The Dienyl Pauson-Khand Reaction
- Diastereoselective Temporary Silicon-Tethered Ring-Closing-Metathesis Reactions with Prochiral Alcohols: A New Approach to Long-Range Asymmetric Induction
- A Water-Soluble and “Self-Assembled” Polyoxometalate as a Recyclable Catalyst for Oxidation of Alcohols in Water with Hydrogen Peroxide
- Synthesis and Scale Up of the Tissue Selective Estrogene ZK 186619
- Highlights from the 7th International Conference on Organic Process Research and Development
- The Monolith Loop Reactor
- Uses and Abuses of Statistical Experimental Design
- The Impact of a tert-Butyl Group
- The Pauson-Khand Reaction: the Catalytic Age Is Here
- Construction of Quaternary Stereocenters: New Perspectives through Enantioselective Michael Reactions
- Diastereoselective Temporary Silicon-Tethered Ring-Closing-Metathesis Reactions with Prochiral Alcohols: A New Approach to Long-Range Asymmetric Induction
- Selective C-Arylation of Free (NH)-Hetroarenes via Catalytic C-H bond Functionalisation
- Highlights from Chiral Europe, London, 12-14th May 2003
- Crafting Chiral Space for Asymmetric Induction in a Catalytic Synthetic Reaction, Keynote Lecture 1
- Evolutionary and Combinatorial Methods in Asymmetric Catalysis
- Design, Performance, Manufacture and Industrial Use of Chiral Ligands
- Benefits and Limitations of chiral resolution via preferred crystallisation
- Cyclopropanation via a Simple Barbier Reaction in DMF
- A Simple Protocol for Direct Reductive Amination of Ketones and Aldehydes (including a.b-unsaturated carbonyl compounds)
- Pyrrolidine-2-carboxylic acid (L-Proline) as an enantioselective catalyst
- Superacid Catalysed Hydroxyalkylation of Aromatics with Ethyl Trifluoropyruvate (A New Route to Mosher’s Acid Analogues)
- Polymethylhydrosiloxane (PMHS) as an Additive in the Sonogashira Reaction
- One-pot synthesis of dihydropyrimidinones catalysed by lithium bromide: an improved procedure for the Biginelli reaction
- Direct Synthesis of Propylene Oxide with CO2 as Solvent
- Direct Sulphonation of Methane to Methanesulphonic Acid with SO2 Using Ca Salts as Promoters
- Palladium-Catalysed Asymmetric Addition of Pronucleophiles to Allenes
- Intramolecular [4+2] Cycloadditions of iminoacetonitriles: A New Class of Azadienophiles for Hetero Diels-Alder Reactions
- Novel Small Organic Molecules for a Highly Enantioselective Direct Aldol Reaction
- A Water-Soluble and “Self-Assembled” Polyoxometalate as a Recyclable Catalyst for Oxidation of Alcohols in Water with Hydrogen Peroxide
- Synthesis and Scale Up of Chiral Alcohols and Epoxides
- BoPhoz Ligands for Asymmetric Catalysis
- Fluorous Phase Catalysis
- Variable Residence Time Reactor
- Novel Enolate Generation
- Michael Additions Catalysed by Bismuth Nitrate
- Alternative Oxidising Agents
- Topics in Stereochemistry – Crystallisation of Diastereoisomers
- Addition of Grignard Reagents to Nitroarenes
- Aerobic Oxidation of Amines to Nitriles Catalysed by Ruthenium on Alumina
- Catalytic Propargylation of Aromatics
- Organocatalysed Enantioselective Reactions
- Oxidation of Cyclohexene to Adipic Acid
- Fosinopril – Synthesis and Separation of Isomers
- Second Generation Process Development
- A Highly Toxic (Carcinogenic) Impurity in a Drug Substance required a specification as low as 0.000007%
- Aerobic Oxidation Of Alcohols Using Polyoxometalate Catalysts With Nitroxyl Radicals
- Epoxidation Of Allylic Alcohols In Aqueous Solutions Of Simple Sugars
- Impurities Derived From Reduction By Sodium Alkoxides, And Formylating Reagents Derived From Ethereal Solvents
- Catalytic Asymmetric Transfer Hydrogenation
- A Safe and Scaleable Amine to Nitrone Oxidation
- Green Route to Fluoroaromatics
- Water Based Organic Synthesis
- Explosion Kills Three
- Inadvertent Production and Explosion of Liquid Chlorine Dioxide
- Practical Recycle of Palladium Catalyst for Heck Reactions
- Efficient One-Pot Synthesis of the Side-Chain of a New Antiobiotic, Ertapenem
- Asymmetric Phase-Transfer Catalysis
- Oligonucleotides
- Validation of Cleaning Processes – New Methodology
- Other Highlights
- A Chemoselective Reduction of Alkynes to E Alkenes
- An Efficient Copper Catalyst for the Amidation of Aryl Halides
- Stereoselective Intramolecular Hydroamination
- Asymmetric Epoxidation Using Phase Transfer Catalysis (PTC)
- Asymmetric Hydrovinylation
- Enantioselective Synthesis of β-lactams
- Role of CO in Molybdenum-Catalysed Asymmetric Alkylations
- A Self Generating Highly Active, Recyclable Olefin Metathesis Catalyst
- Highlights of the Large Scale Chromatography Conference, Boston 16/17th September 2002
- Enantioselective Organo Catalytic 1,4-Addition of Electron-Rich Benzenes to Unsaturated Aldehydes
- Melt Crystallisation – How to Purify Organics without using a Solvent
- New Palladium-catalysed Reduction of Acids to Aldehydes
- Tributylphosphine Catalysed Stetter Reaction
- Side Reactions in Baylis-Hillman Reaction in Ionic Liquids
- Novel Way of Generating Singlet Oxygen
- The Eenie-Meenie Reactions
- Tandem Reactions Yield Spiro Products
- Stereocontrolled Mannich Reaction With Enolisable Imines
- Conversion of N-Aromatic Amides to O-Aromatic Esters
- A New Base For Selective Deprotonation of Weak CH Acids
- Enantioselective Synthesis of β-lactams
- Preparation of Nitro-functionalised Organo
- Enantiomeric Partioning Using Fluorous Biphase Methodology
- Catalytic Enantioselective Synthesis of β-Amino Acids
- Asymmetric Ring Opening of Epoxides with Silicon Tetrachloride
- A Review from the 6th International Conference on Organic Process Research and Development
- Recovery Of Rhodium Containing Catalysts
- Using Phase Transfer Catalysis In Borohydride Reductions
- Bismuth(III) Chloride and Triflate - Novel Catalysts for Arylation and Sulphonation Reactions - Review
- Direct Thioesterification Of Carboxylic Acids With Thiols
- Catalytic Reactions in Ionic Liquids
- Efficient, Catalytic Aerobic Oxidation of Alcohols with Octahedral Molecular Sieves
- Hydrolytic Kinetic Resolution (HKR) Of Terminal Epoxides
- Enantioselective C-C Bond Cleavage Of Cyclobutanols
- Synthesis Of ß-Lactones By Epoxide Carbonylations
- Source Of Carbon Monoxide Affects The Reactions
- Intramolecular Tischenko Reaction To Give Phthalides
- Enantioselective Organocatalytic Indole Alkylations
- Regioselective Metallation Of Bromopyridines
- Large Scale Reactions At Low Temperature (Down To -100 oC)
- Emergency Relief And Containment For Hazardous Processes
- Diazo and Azides - Hazards
- Choosing Filtration Equipment
- Microreaction Engineering - Is Small Better?
- Raman Spectroscopy for On-Line Analysis and Process Control During Manufacture
- Understanding the Nature of Heterogeneous Chiral Catalysts in the Asymmetric Reduction of Ketoesters
- Meta-Activated Nucleophilic Substitution - use in Preparation of Polymers
- Asymmetric Catalysis on Sequentially Linked Columns
- Twelve More Green Chemistry Principles
- Practical Use of Continuous Processing in Developing and Scaling Up Laboratory Processes
- Asymmetric Oxidation Reactions
- Hydroformylation of Allylic Ethers; Regio - and Diastereoselectivity
- Efficient Catalysts for the Coupling of CO2 with Epoxides to give Cyclic Carbonates. Possible Chemical Carbon Dioxide Fixation
- Versatile Cyclopentenone Synthesis by Intramolecular Hydroacylation of Alkynes
- Fluorous Catalysis without Fluorous Solvents
- Acids and Bases in One Pot while avoiding their Mutual Destruction
- Mild and Effective Transesterification Catalysts
- A New Dynamic Resolution Process - Coupled Feverse Michael Addition and Enzymatic Hydrolysis
- Novel Preparation of b-lactones
- Stereoselective aldol reactions in water
- Preparation of b-lactones by carbonyl insertion into expoxides
- Asymmetric Birch reduction in furans
- Organic catalyst for Michael additions
- Alkylation of acetylenes - new catalysts
- Use of diazomethane derivatives for the Wittig reaction
- Practical synthesis of trans-sabinene, suitable for scale up
- Baylis-Hillman reaction under aqueous conditions
- New catalyst for carbonylation of aryl chlorides to aryl esters
- A spinning Disc Reactor can offer advantages over conventional reactors in pharmaceutical Process R & D
- Let automation do the work for you when optimising partial reduction during a multi-step catalytic hydrogenation
- An improved iodination of aromatic compounds gives higher yields using cheaper reagents
- When should optimisation of a synthetic reaction be carried out and what methodology should be used?
- Boronic acids can be used as viable alternatives to borinic acids in Suzuki coupling reactions.
- Scale-up of a Sonogoshira coupling required modifications to improve product isolation and minimise heavy metal contamination.
- Structurally similar compounds often require quite different synthetic strategies
- Highlights from Literature
- Current Newsletter||Links to many useful articles
- Newsletter Archive||Useful articles from past newsletters
