ADME and hERG in Medicinal Chemistry

29 - 30 October 2008, Basel, Switzerland

A 2 day course given by
Dr Corinne Kay, Med-Simple

In addition to maintaining their sound synthetic organic chemistry knowledge, Medicinal Chemists have to address complex ADME (Absorption, Distribution, Metabolism and Elimination) and pharmacology issues on a day to day basis. Although relevant principles of pharmacology can be picked up from traditional medicinal chemistry books, much of the wisdom required to progress projects takes years to acquire and many ‘tricks of the trade.’ These are often concealed within a profusion of medicinal chemistry papers. Distilling practical help from the literature itself requires experience as well as time.

‘ADME - hERG – Succeed through the Literature’ is a new, interactive approach to learning medicinal chemistry.

The course is divided into self-contained blocks that require no prior knowledge of the topic. It spans the foundations of ADME as well as all relevant terms in pharmacokinetics. The hERG topic is treated in two parts: a comprehensive introduction to the topic and a comprehensive up to date review of the literature. Each block first gives sound background to the topic and then focuses on distilling ‘solutions’ from past and current literature, enabling participants to become effective and productive readers of the literature, thus promoting innovation. New concepts are applied in realistic group sessions which are designed to mimic real life situations.

The uncluttered and highly practical teaching style has been tried and tested in a number of pharmaceutical companies as well as in academia and has received much positive feedback.

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The organisers reserve the right to change the published programme of events and course content as circumstances dictate.