Course Outline

DAY 1 (am)

Process development for Scaleability

• Characteristics of successful processes
• Process development strategies
• Overview of scale-up issues
• Documentation for technology transfer

The Batch Pilot Plant

• The role of the pilot plant
• Typical operations and equipment
• Characteristics of batch operations

Process Walk-Through

• Raw material and route selection
• Charging raw materials
• Handling hazardous materials
• Heat transfer in batch reactors
• Controlling exothermic reactions
• Monitoring reaction progress

DAY 2

Process Walk-Through (cont.)

• Mixing effects in batch reactors
• Reaction quench and workup
• Liquid-liquid extractions
• Distillation and stripping operations
• Crystallization and precipitation
• Solid product isolation and scale-up
• Solid product drying and post-treatment
• Recap of scale-up issues

DAY 3 (am)

Chemical Process Safety

• Principle hazards in batch operations
• Assessing flammability, explosivity, reactivity
• Introduction to HAZOP and safety evaluations

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