Fees
- The course fee is £
- Refreshments & lunch each day
- Dinner on Tuesday 9 October
- The comprehensive course manual
General Information
The course will begin with registration at 8.30am on Tuesday 9 October and will end after lunch on Thursday 11 October 2007.
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A 3 day course given by Professor Victor Snieckus, Queen's University, Canada
Introduction
Aims of the Course
a) to provide a conceptual framework for the multitude of reactions currently emanating from the impact of transition metal catalysis on the field of aromatic and heteroaromatic synthesis and to place it into practical perspective;
b) to present a systematic picture of C-C bond coupling methods (Suzuki-Miyaura, Negishi, Kumada-Corriu, Stille, and, most recently, Hiyama) according to hybridization format, e.g. sp2-sp2, sp2-sp3, inter alia
c) to survey other rapidly evolving synthetically promising catalytic processes (Buchwald-Hartwig, Heck, Ullmann, Sonogashira, Grubbs) in a systematic manner using C-N, C-O, C-S formalism;
d) to connect directed ortho metalation (DoM) strategies to these blossoming areas of transition metal catalysed processes;
e) to contrast and compare the above modern processes with classical but still useful synthetic methods.
The desired consequence is the facility (both on paper and in the lab!) to use these modern strategies for the regiospecific construction of polysubstituted aromatic/heteroaromatic systems and for the rational assemblage of complex bioactive molecules and natural products. Normal synthetic and mechanistic organic knowledge will be assumed. Retrosynthetic analysis, specific mechanistic features of old and new reactions, and theoretical basis of synthetic principles will guide the presentation, discussion and problem solving sessions.
The course participants should have the expectation of achieving a thorough understanding of these modern strategies and methods which will hopefully stimulate new thinking for the solution of current problems in discovery, medicinal, and process laboratories. Extensive reference are provided in the comprehensive course manual of 300+ pages.
Constructed and regularly updated with the invaluable assistance of current members of the VS Group.
The organisers reserve the right to change the published programme of events and course content as circumstances dictate.