Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries

Principles and Practice

23 - 25 September 2008, Budapest, Hungary

given by Dr Will Watson and Dr Derek Robinson, Scientific Update

Chemical process development is generally not taught as part of degree courses in higher education; the conversion of a synthetic route used for making milligram or gram quantities of a chemical into a process for manufacturing multi-kilogram and tonne quantities is typically learnt “on the job” by chemists in industry. For many years, little chemical development work was published in the literature, until the establishment of the Organic Process R & D journal by Dr Trevor Laird (Founder of Scientific Update). Even now, “tricks of the trade” are handed down within individual company organisations, and it can be difficult to gain an awareness of what is involved in chemical development, and of the skills and techniques required to efficiently scale up chemical processes. 

This three-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced during chemical development.

Course Objectives - What does the course set out to achieve?

• To train R and D chemists and engineers in the most efficient methods for developing cheap, robust processes used to manufacture fine organic chemicals in the minimum amount of time.
• To educate chemists in the principles of scale-up and development, in basic chemical engineering concepts and in techniques for the optimisation of processes.
• To educate chemists to learn from the experience (and mistakes) of others by examining case studies from industry.

At the end of the course participants will have gained:

• A logical investigative approach to chemical development and optimisation.
• An insight into the factors involved in development and scale-up.
• An appreciation of chemical engineering concepts, particularly mixing, heat transfer and process control.
• A preliminary knowledge of statistical methods of optimisation.
• Improved ability to decide which parts of the chemical process to examine in detail
• Ideas for efficient resource allocation
• Improved troubleshooting and problem solving ability

The organisers reserve the right to change the published programme of events and course content as circumstances dictate.