The Latest Process Chemistry you won't find anywhere else...

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A 2 day course given by

Introduction

Optically active compounds are increasingly important in organic chemistry and in industry. Approximately half of the thousands of drugs known have chiral structures, many of which show dramatic differences in the properties of the stereoisomers (enantiomers) and thus an increasing proportion are marketed as single enantiomers. In the agrochemical field, many marketed compounds have been “switched” from a racemic to single enantiomer form for environmental reasons, since the inactive isomer contributes to pollution. In the flavour and fragrances industry and in molecular electronics, chirality is a key issue in R&D and manufacture.

The rational synthesis of the growing number of chiral chemicals (drugs, agrochemicals etc and intermediates) either on a laboratory or industrial scale, calls for efficient methods for providing these compounds in enantiomerically pure form.

Although many strategies may be considered (asymmetric synthesis, synthesis from the chiral pool, chromatography etc), optical resolution via diastereomeric salt formation remains the most widely used method for preparing pure enantiomers, both in the lab and in production.

This course covers in detail this important chemical process. The physico-chemical background on enantiomeric and
diastereomeric mixtures will be presented, as well as the theory and practice. The theory is necessary to be able to devise and understand the practical methods for resolving compounds and to understand the critical parameters (choice of solvent, stoichiometry, resolving agent, concentration etc) to achieve the desired result. A large number of examples from the literature from industrial practice will be presented.

 

The organisers reserve the right to change the published programme of events and course content as circumstances dictate.