The Latest Process Chemistry you won't find anywhere else...

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A 2 day course given by Professor Jonathan Percy, University of Strathclyde

Introduction

Fluorinated organic molecules are of growing interest because of their frequent occurrence in modern agrochemicals, drug molecules and materials. The course is intended to introduce a broad area of current relevant fluorine chemistry to researchers from the chemical and pharmaceutical industries. We will discuss methods for the synthesis of a range of different types of fluorinated molecules including not only fluoro- and trifluoromethyl arenes, but also species bearing less common but important fluorinated substitutents (-SF₅ - OCF₃ and other groups).

Fluoroaliphatic species, though less common in end-products, are important and we will review methods for their synthesis. Fluorination technology will be reviewed and biophysical consequences of fluorine atom incorporation will be described.

 

Course Outline

There are a number of main themes;

• Fluorination reagents (Nucleophilic and Electrophilic)
• Aliphatic fluorinated building blocks; commercial starting materials for the synthesis of selectively fluorinated molecules
• Fluorinated and perfluoroalkylated arenes and heteroarenes; synthesis by fluorination perfluoroalkylation and de novo assembly
• Fluorous chemistry; reagents and separation methods
• Biophysical consequences of fluorination, fluorine and pKa, lipophilicity, hydrogen bonding, electron availability, isosterism, mimicry and modes of action of selected bioactive compounds

Four workshops will consolidate and develop the ideas contained in the course material.

 

The organisers reserve the right to change the published programme of events and course content as circumstances dictate.