Heterocyclic Synthesis in Modern Chemistry
26 - 27 June 2008, Nice, France
A 2 day course given by Professor Joe Sweeney, University of Reading
Introduction
This is a 2-day course which has been designed specifically for chemists who have a basic understanding of the principles of aromatic heterocyclic chemistry, and seek to develop their skills, using retrosynthetic analysis to advance their knowledge of the area.
The course lectures (and the associated detailed course manual, containing all slides used by the course tutor) will describe the main synthetic methods used to prepare heterocycles of academic and commercial significance, drawing attention to the retrosynthetic principles which underpin the reactions. In addition to the lecture material, the course will also be built around an equal number of workshops: each workshop will consists of a case-study focused upon ‘real-world’ examples of heterocyclic synthesis (taken from industrial projects and/or commercial processes), and the associated retrosynthetic analysis.
Rather than giving delegates a lengthy list of named reactions, the aim of this course is to provide a meticulous grounding in the common principles of synthetic heteroaromatic chemistry, enabling those attending to analyze their own synthetic targets from a more rational perspective, and to reinforce their retrosynthesis skills. Compound classes covered during the course include pyrroles, furans, thiophenes, indoles, benzofurans and benzothiophenes, diazoles (oxazoles, imidazoles, thiazoles and benzo analogues), pyridine, quinolines, isoquinolines (and benzo analogues), diazines (pyrimidines, pyrazines, pyridazines and benzo analogues); there will also be a lecture and workshop devoted to the use of metal-catalyzed reactions (primarily palladium-mediated processes) in modern heterocyclic synthesis, and the course will conclude with a practice session where delegates will work in small groups to devise their own retrosyntheses for significant hetarenes.
The organisers reserve the right to change the published programme of events and course content as circumstances dictate.
