Fees
The course fee is £995
- Lunch & refreshments daily
- A copy of the comprehensive course manual
General Information
The course begins with registration from 08.30 on Tuesday 21 October and finishes at approximately 16.00 on Wednesday 22 October 2008.
Practical Phase-Transfer Catalysis
Given by PTC Communications
21 - 22 October 2008, Barcelona, Spain
A 2 day course given by Dr Marc Halpern, PTC Communications
“Practical Phase-Transfer Catalysis” is a 2-day course which provides a structured approach and broad applications for developing high-performance and low-cost processes using phase-transfer catalysis. Practical guidelines focus on achieving high yield, high selectivity, short reaction time, avoiding isolation of intermediates, solvent-free PTC, replacing expensive hazardous strong base with inexpensive inorganic base, reducing excess reactants and enhancing safety & environmental performance.
Course Outline
Registration
Introduction
Phase-Transfer Catalysis Overview
PTC Mechanism
“I-Reaction” and “T-Reaction”
The PTC Rate Matrix
Introduction to Understanding Interactions Between Catalyst, Hydration, Solvent and Anions
Morning Break
Choosing Process Parameters
Choosing Catalyst
Structure Activity Relationships
including systematic approach for predicting and selecting catalyst for reactivity
effective catalyst separation methods
including minimizing residue and waste
catalyst recycle
catalyst stability
toxicity
availability
Lunch
Choosing Process Parameters - continued
Anions, Leaving Group and Catalyst Poisoning
Hydration (dramatic effects and control)
Practical Aspects of Solvent
Solvent-Free PTC
Agitation
“Third Phase” PTC (not triphase PTC)
Afternoon Break
Practical Guidelines
Guidelines for Identifying, Evaluating and Optimizing New PTC Applications
A 3-5 Experiment Program for Screening & Resource-Efficient R&D
Patentable Opportunities
Identifying Opportunities
The 60-Second PTC Test
Group Exercises
End of Day One
Applications - Strong Base Reactions
C-Alkylation
Chiral Alkylation
O-Alkylation
S-Alkylation
N-Alkylation
Morning Break
Applications - Strong Base Reactions - continued
Michael Addition
Aldol Condensation
Wittig, Darzens
Other Condensations
Dehydrohalogenation
Carbene Reactions
Applications - Nucleophilic Substitutions
Esterification
Transesterification
O-Acylation & Thiophosphorylation
Use of Water-Sensitive Reactants in PTC Substitutions
Lunch
Nucleophilic Substitutions - continued
Cyanide
Azide
Fluoride
Other nucleophilic aliphatic and aromatic substitutions
Applications - Oxidation
Oxidations
Hydrogen Peroxide
Hypochlorite
Other oxidizing agents
Epoxidations
Afternoon Break
Applications - Reduction & Other Reductions
Borohydride
Hydrogenation
Other reducing agents
Transition Metal Co-Catalysis
Additional PTC reactions and exercises
Course Conclusion
The organisers reserve the right to change the published programme of events and course content as circumstances dictate.