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Training Courses

Event 

Title:
Chemical Development & Scale-Up in the Fine Chemical & Pharmaceutical Industries
Subtitle:
Principles and Practice
When:
08.02.2012 - 10.02.2012
Tutors:
Where:
The Sea Princess Hotel - Mumbai
Brochure:
View Brochure

Description

Chemical process development is generally not taught as part of degree courses in higher education; the conversion of a synthetic route used for making milligram or gram quantities of a chemical into a process for manufacturing multi-kilogram and tonne quantities is typically learnt “on the job” by chemists in industry. For many years, little chemical development work was published in the literature, until the establishment of the Organic Process R & D journal by Dr Trevor Laird (Founder of Scientific Update). Even now, “tricks of the trade” are handed down within individual company organisations, and it can be difficult to gain an awareness of what is involved in chemical development, and of the skills and techniques required to efficiently scale up chemical processes. 

This three-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced during chemical development.

  • Introduction
    The purpose of chemical development

    Synthetic Route Discovery
    Route design
    Selecting the best route for scale-up
    Choice of raw materials, reagents etc

    Costing of Chemical Processes
    Raw materials
    Overheads
    Contex

    The Investigative Approach to Chemical Development
    Optimising Chemical Reactions
    Making processes robust
    Minimising scale-up difficulties

    Solvent Effects
    Often overlooked
    Key to making a modest process a great proces

    Statistical Methods of Optimisation
    Vital, but under-utilised
    Design of Experiments
    Simplex
    Factorial design

    Analytical Issues
    In Process Control
    Quality Control and Specification Setting
    Regulatory Guidelines
    GMP, Validation
    Use of analysis to aid process optimisati

    Work Up
    Product isolation

    Planning for Scale-Up
    Key points to conside

    Appreciation of Chemical Engineering Principles
    Mass Transfer
    Mixing
    Heat Transfer
    Kinetics

    Crystallisation and Polymorphism
    Particle size control
    Polymorph control
    Methods of analysis

    Chemical Development of Enantiomerically Pure Compounds
    Resolution
    Chemocatalysis
    Biocatalysis
    Crystallisation-induced asymmetric transformations

    Thermal Hazard Testing and Runaway Reactions
    Essential process safety considerations
    Equipment and screening approaches

    Effluent Minimisation and Control
    Environmental considerations
    Cost considerations
    Green chemistry

    • To train R and D chemists and engineers in the most efficient methods for developing cheap, robust processes used to manufacture fine organic chemicals in the minimum amount of time.
    • To educate chemists in the principles of scale-up and development, in basic chemical engineering concepts and in techniques for the optimisation of processes.
    • To educate chemists to learn from the experience (and mistakes) of others by examining case studies from industry.
  • At the end of the course participants will have gained:

    • A logical investigative approach to chemical development and optimisation.
    • An insight into the factors involved in development and scale-up.
    • An appreciation of chemical engineering concepts, particularly mixing, heat transfer and process control.
    • A preliminary knowledge of statistical methods of optimisation.
    • Improved ability to decide which parts of the chemical process to examine in detail
    • Ideas for efficient resource allocation
    • Improved troubleshooting and problem solving ability
    • Young Chemists who have just started work in industry as development chemists
    • Organic Chemists/Medicinal Chemists in Research and Development who would like to gain an appreciation of development and scale up and who are perhaps contemplating moving into chemical development.            
    • Development and Production Chemists in industry who would like to improve their efficiency and gain an insight into alternative approaches to chemical development.
    • Chemical Engineers who wish to understand a chemist’s approach to chemical development of batch processes. (Engineers would, however, need a good grounding in organic chemistry)
    • Students who are about to enter the industry and can obtain company sponsorship.
    • Experienced Chemists looking to refresh and/or augment their knowledge of chemical development
    • Analytical Chemists who wish to gain a broader appreciation of process chemistry
    • Managers who might benefit from a comprehensive and up to date overview of chemical development
  • "The course was excellent in general.  In particular, the breadth of subjects that were covered in a very clear and concise manner, plus the format and number of problem sessions, were excellent in my opinion.  High quality handouts with a wealth of literature references."   Novexel SA

    "Very well organised.  Problem sessions are a really good idea.  The literature information in the manual is very helpful."   Boehringer Ingelheim

    "Very useful and enjoyable - thanks!"   Hospira Boulder Inc

    "The course was helpful and the presenters were fantastic - extremely knowledgeable and easy to talk to."   Millennium: The Takeda Oncology Co

    "I love the small group problem solving sessions."   Vertex

Fee Information

Course Fee:
£595
Multi Discount:
SAVE 5% for 2 attendees and 15% for 3 attendees

Venue

The Sea Princess Hotel
Venue:
The Sea Princess Hotel   -   Website
Street:
Juhu Beach
Postcode / ZIP:
400 049
City:
Mumbai
Country:
Country: in

Description

The Hotel Sea Princess is located in the heart of Mumbai on the famous beach of Juhu and facing the sea. A government classified Five Star hotel, it has a blend of old charm and contemporary amenities which make the hotel most popular amongst business and holiday guests.

Service and facilities at the hotel include a 24 hour coffee shop, the Ark bar, health club and lagoon swimming pool, beauty parlour and gift shop. The restaurants are Princess lounge and Orient, serving Chinese, Continental and Indian cuisine. The pool side garden can accommodate up to 2000 people for any occasion. It has a reputation for excellence in housekeeping and personalised service.

Directions:

The hotel is approximately 8 Km from the domestic airport and 13 Km from the international airport and 30km from downtown Mumbai (Capital of Maharashira).

By Air: Sahar International Airport and Santacruz Domestic Airport