Training Courses

This course is intended to provide a thorough update of recent developments in the synthesis and subsequent transformations of heterocyclic aromatic compounds. The lectures briefly reprise ‘classical’ methods used for the synthesis of aromatic heterocycles containing nitrogen, oxygen and sulphur and build upon these concepts by focusing upon advances made in the area during the last decade. Improved classical processes and any new reactions described are thoroughly delineated in problem classes held in tutorial format.

Who Should Attend?

This course has been designed to be of benefit to a wide range of industrial chemists, specifically those already familiar with the principles of aromatic heterocyclic (‘heteroaromatic’) chemistry or for those who have already attended the “Essential Aromatic Heterocyclic Chemistry” or “Heterocyclic Synthesis in Modern Chemistry” courses.
This course is suitable for scientists at graduate level and above. 

Programme

Introduction

Comparison of strategies for heteroaromatic synthesis:
‘classical’ methods
transition-metal catalysed processes
modern methods

Recent Developments in the Synthesis and Reactions of:

Monocyclic, five membered monoheteroaromatic rings:
pyrroles, furans, thiophenes

Bicyclic, five-membered monoheteroaromatic rings:
indoles, isoindoles,
benzofurans, isobenzofurans,
benzothiophenes and isobenzothiophenes

Mono- and bicyclic, five-membered diheteroraomatic rings:
imidazoles, pyrazoles,
benzimidazoles, benzpyrazoles,
oxazoles, isoxazoles,
benzoxazoles, benzisoxazoles
thiazoles and isothiazoles,
benzothiazoles

Monocyclic, five membered triheteroaromatic rings:
triazoles, oxadiazoles, thiadiazoles

Monocyclic, five-membered tetraheteroaromatic rings:
tetrazoles

Mono- and bicyclic, six-membered monoheteroaromatic rings:
pyridines,
quinolines and isoquinolines

Mono- and bicyclic, six-membered diheteroaromatic rings:
pyrimidines, pyrazines, pyridazines,
quinoxalines, quinazolines and cinnolines