Process Chemistry News
A NEW Book written by L A (Bert) Hulshof
Scientific Update LLP (SU) have published a new book which falls into the theme expressed on many SU courses and conferences, namely trying to bring chemists and chemical engineers closer together to help with transfer of processes from Lab to Plant.
The book, “Right First Time in Fine Chemical Process Scale Up” has been written by Dr Bert Hulshof, formerly of DSM and the University of Eindhoven in the Netherlands, who suggests that the key to success is to avoid scale-up problems.
We are all quite familiar with enzyme-mediated kinetic resolution of alcohols and of course have become accustomed to the extremely high enantiomeric excesses (ee’s) that can be achieved.
As a process chemist I like to look for unexpected chemistry and also chemistry which, under the wrong circumstances could result in reaction side-products and/or impurities. As a result I look out for reactions involving solvents, or at least ‘reactants’ typically regarded as ‘solvents’ as illustrated by these two cases.