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Process Chemistry News

Systematic Method to Develop/Optimize PTC Processes

Written by Dr Claire Francis on Monday, 02 March 2015. Posted in Process Chemistry News

Marc Halpern, the leading expert in industrial phase-transfer catalysis, asks you to imagine a systematic method to rapidly develop and optimize process conditions for low-cost high-performance phase-transfer catalysis reactions! Would you use the systematic method?

That systematic method exists and it's called the "PTC pKa Guidelines" (Halpern, M.; Ph.D. Thesis, Hebrew University of Jerusalem, 1983).

Halpern Guidelines

 

Marc Halpern, the leading expert in industrial phase-transfer catalysis. - See more at: http://phasetransfercatalysis.com/ptc_tip/systematic-method-to-developoptimize-ptc-processes/#sthash.TG8lk1E0.dpuf
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Appearing and Disappearing Polymorphs

Written by Dr Will Watson on Friday, 13 February 2015. Posted in Process Chemistry News

Dr Trevor Laird (Scientific Update) talked about appearing and disappearing polymorphs and other solid forms in process development, during the '2nd Winter Process Chemistry' Conference in December. This involved a number of case studies including axitinib, Pfizer's anti-cancer drug, has 5 anhydrous forms and over 70 different solvates known to date and requires a complex crystallisation wash procedure to obtain the correct form. In another example from Merck-Schering Plough batches from one reactor train started to fail because of a yellow colouration. Product from an older reactor train did not have this problem. Temperature and humidity, particularly during drying were found to be critical. During drying a new anhydrate was being formed which then formed a new hydrate when exposed to moist air. The new hydrate is unstable forming the yellow impurity. The problem was solved by a modified wash and drying sequence.

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Biocatalytic Cascade Syntheses

Written by Dr Will Watson on Friday, 13 February 2015. Posted in Process Chemistry News

Professor Nick Turner (University of Manchester) was the keynote speaker on the topic of biocatalysis, which was the special topic for the conference. The presentation covered a variety of new developments in the area of biocatalysis as well as highlighting the improvements that have taken place over the last 10-15 years. The final part of the talk covered biocatalytic cascade reactions where two or more enzymes are used in conjunction for example taking a 1,4-diketone and reacting it with an –transaminase and a monoamine oxidase and NH3:BH3, to produce enantiomerically pure pyrrolidines as shown below:

Turner1

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Process Chemistry Training & Conferences

Scientific Update, established in 1989 by Dr. Trevor Laird, organises conferences and training courses for industrial chemists and chemical engineers in chemical development and scale-up and many other specialist topics in organic chemistry. We also provide extensive consultancy services in these fields and edit the international scientific journal entitled Organic Process Research and Development (OPRD).

Our short intensive training courses enable scientists to learn about highly relevant topics, to broaden their knowledge and to keep abreast of new science, new technology and new techniques. A complete list of the scheduled training courses currently available can be viewed in the training section. Many of these are also available for in-house training.

Our specialist conferences provide the perfect forum for organic process chemists and chemical engineers to network with experts from industry and academia from all over the world.

Our aim is to provide you with the very best, up-to-date chemistry and superb locations. At every event, Scientific Update provide the highest quality organisation and friendly support from all our team.  We look forward to welcoming you to one of our events soon.

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