Process Chemistry News
OPRD has just published as an ASAP article a long and very comprehensive multi-author review (with hundreds of up-to-date references) showing the state of the art in PAT. (Levente S; doi 10.1021/op500261y). It is particularly strong in crystallisation technologies and has some good industrial case studies. The review forms part of a special feature section devoted to PAT which will appear in the Jan 2015 edition of OPRD.
Workers at Merck wanted to hydrolyse nitrile (20) to acid (2), so they chose to heat the nitrile in 5N HCl at 40°C. They were somewhat surprised to obtain the desired acoid (2) contaminated with isomer (21) formed in up to 15% yield or a ratio of 89:11.
Review of 'Organic Process R&D' Conference India and '2nd Winter Process Chemistry' Conference, UK
It's been a very busy end of 2014 for us at Scientific Update with a range of courses to deliver and conferences to attend. During the period September to end December Will and I delivered courses in France, Hungary, USA, Canada, Hungary (again), Scotland, France (again), Germany, India and England. We have also attended Scientific Update conferences during this time in Germany, India and UK. As a result I am a bit behind with my literature reading, but thought it would be interesting to comment on just a few of the titbits that stood out for me from the conferences mentioned above.